Individual custom layouts

I’m considering rearranging the number row with the traditional odd/even Dvorak split, but for some reason I felt like I shouldn’t because of the F1-12 keys. Now I’m not sure why it didn’t occur to me to re-order the function keys, too. Either way, I want to try that row shift-inverted, though.

@algernon, can you tell me how tricky it will be for me to configure (for example) shift + , to produce ;, given that they’re not on the same key on the keyboard the OS is set up for?