I use Key_mouseScrollUp, Key_mouseScrollDown, Key_mouseScrollLeft and Key_mouseScrollRight in Kaleidoscope. It works in some software, but not (or barely) in others.
In Firefox and most others, it works well. In VSCodeium, it does not work at all. In some others (forgot which one), it works intermittently, as in … i push it, it scrolls for a few delay intervals, then stops. if I click a mouse button (also with the Model 01), it again scrolls for a few delays, then stops and continues again if I click the mouse button again.
In all these softwares, the wheel on my physical mouse works flawlessly.