Planning on using one of the thumb keys as a macro to make a full stop (period for the americans), space and capitalise the next letter. So instead of typing “full stop, spacebar, hold down shift and press first letter of next sentence” I can type “macro, first letter of next sentence”.
Was planning to do something like this in autohotkey anyway before I discovered keyboardio, using the regular full stop key (and using a modifier to allow a usual full stop for when I need to use that), but I think it would work even better as a thumb key.